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Agouti-related Protein(AGRP)(25-82),human

貨號(hào) wb2256-1mg 售價(jià)(元) 詢價(jià)
規(guī)格 1mg CAS號(hào)
  • 產(chǎn)品簡(jiǎn)介
  • 相關(guān)產(chǎn)品

貨號(hào)

名稱

規(guī)格

wb2256-1mg

Agouti-related Protein(AGRP)(25-82),human

1mg

wb2256-5mg

Agouti-related Protein(AGRP)(25-82),human

5mg

產(chǎn)品簡(jiǎn)介:

       刺鼠相關(guān)蛋白也稱為刺鼠相關(guān)肽(AgRP ),是大腦中由AgRP/NPY神經(jīng)元產(chǎn)生的神經(jīng)肽。它僅在位于下丘腦弓狀核腹內(nèi)側(cè)部的含有NPY的細(xì)胞體中合成1。Agouti相關(guān)蛋白主要在腎上腺、丘腦底核和下丘腦中表達(dá);在睪丸、腎和肺中表達(dá)水平較低。AgRP的食欲刺激作用被瘦素抑制,被生長(zhǎng)素釋放肽激活。脂肪細(xì)胞分泌瘦素以應(yīng)對(duì)食物攝入。這種激素作用于弓狀核并抑制AgRP/NPY神經(jīng)元釋放食欲肽2。生長(zhǎng)素釋放肽在NPY/AgRP神經(jīng)元上有受體,刺激NPYAgRP的分泌以增加食欲。AgRP儲(chǔ)存在細(xì)胞內(nèi)分泌顆粒中,并通過受調(diào)節(jié)的途徑分泌。AgRP的轉(zhuǎn)錄和分泌作用由炎癥信號(hào)調(diào)節(jié)。禁食期間AgRP水平升高。已經(jīng)發(fā)現(xiàn)AgRP刺激下丘腦-垂體-腎上腺皮質(zhì)軸釋放ACTH、皮質(zhì)醇和催乳素。它還增強(qiáng)ACTH對(duì)IL-1-β的反應(yīng),表明它可能在炎癥的神經(jīng)內(nèi)分泌反應(yīng)調(diào)節(jié)中起作用。

產(chǎn)品性質(zhì):

產(chǎn)品名稱 Agouti-related Protein(AGRP)(25-82),human

別名 H2N-Leu-Ala-Pro-Met-Glu-Gly-Ile-Arg-Arg-Pro-Asp-Gln-Ala-Leu-Leu-Pro-Glu-Leu-Pro-Gly-Leu-Gly-Leu-Arg-Ala-Pro-Leu-Lys-Lys-Thr-Thr-Ala-Glu-Gln-Ala-Glu-Glu-Asp-Leu-Leu-Gln-Glu-Ala-Gln-Ala-Leu-Ala-Glu-Val-Leu-Asp-Leu-Gln-Asp-Arg-Glu-Pro-Arg-OH

分子式 C279H468N80O90S1

分子量 6415.39

溶解度 ≥ 100mg/mL in Water, Limited solubility in DMSO

儲(chǔ)存條件 Store at -20°C